Gluten Free : Some More at Risk of Celiac

By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Pediatrics. According to news reporting from Amsterdam, Netherlands, by NewsRx journalists, research stated, "Coeliac disease (CD) is an immune-mediated systemic condition elicited by gluten and related prolamines in genetically predisposed individuals and characterised by gluten-induced symptoms and signs, specific antibodies, a specific human leukocyte antigen (HLA) type and enteropathy. The risk of coeliac disease is increased in first-degree relatives, certain syndromes including Down syndrome and autoimmune disorders."

The news correspondents obtained a quote from the research from VU University Medical Center, "It is thought to occur in 1 in 100-200 individuals, but still only one in four cases is diagnosed. Small-bowel biopsy is no longer deemed necessary in a subgroup of patients, i.e. when all of the following are present: typical symptoms or signs, high titres of and transglutaminase antibodies, endomysial antibodies, and HLA-type DQ2 or DQ8. In all other cases, small-bowel biopsy remains mandatory for a correct diagnosis. Therapy consists of a strictly gluten-free diet. This should result in complete disappearance of symptoms and of serological markers. Adequate follow-up is considered essential."

According to the news reporters, the research concluded: "Although small-bowel biopsy may be omitted in a minority of patients, small-bowel biopsy is essential for a correct diagnosis of CD in all other cases. Diagnostic work-up should be completed before treatment with gluten-free diet instituted."

For more information on this research see: Clinical practice : coeliac disease. European Journal of Pediatrics, 2012;171(7):1011-21. European Journal of Pediatrics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer -; European Journal of Pediatrics -

Our news journalists report that additional information may be obtained by contacting C.M. Kneepkens, Dept. of Paediatrics, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands (see also Pediatrics).

Publisher contact information for the European Journal of Pediatrics is: Springer, 233 Spring Street, New York, NY 10013, USA.

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